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Stages of HIV Infection

1) Acute Infection: During this time, large amounts of the virus are being produced in your body. This has been described as feeling like the 'worst flu ever'. 2) Clinical Latency: This stage of the disease, HIV reproduces at very low levels, although it is still active. During this period you may not have symptoms and this can last up to 8 years or longer. 3) AIDS: As your CD4 cells fall below 200 cells/mm3 you will be diagnosed as having AIDS. Without treatment people typically survive 3 years.
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WHAT are the stages of hiv infection?

HIV infection has a well-documented progression. If you are infected with HIV and don’t get treatment, HIV will eventually overwhelm your immune system. This will lead to your being diagnosed with Acquired Immune Deficiency Syndrome (AIDS).

However, there’s good news: when used consistently, antiretroviral therapy (ART) prevents the HIV virus from multiplying and from destroying your immune system. This helps keep your body strong and healthy by helping you fight off life-threatening infections and preventing HIV from progressing to AIDS. In addition, research has shown that taking ART can help prevent the spread of HIV to others. (Read more about HIV treatment.)

Below are the stages of HIV infection. People may progress through these stages at different rates, depending on a variety of factors.

acute infection stage

Within 2-4 weeks after HIV infection, many, but not all, people develop flu-like symptoms, often described as “the worst flu ever.” Symptoms can include fever, swollen glands, sore throat, rash, muscle and joint aches and pains, fatigue, and headache. This is called “acute retroviral syndrome” (ARS) or “primary HIV infection,” and it’s the body’s natural response to the HIV infection.

During this early period of infection, large amounts of virus are being produced in your body. The virus uses CD4 cells to replicate and destroys them in the process. Because of this, your CD4 count can fall rapidly. Eventually your immune response will begin to bring the level of virus in your body back down to a level called a viral set point, which is a relatively stable level of virus in your body. At this point, your CD4 count begins to increase, but it may not return to pre-infection levels. It may be particularly beneficial to your health to begin ART during this stage.

It is important to be aware that you are at particularly high risk of transmitting HIV to your sexual or drug using partners during this stage because the levels of HIV in your blood stream are very high. For this reason, it is very important to take steps to reduce your risk of transmission.

For more information, see NIH’s Guidelines for the Use of ART in HIV-1-Infected Adults and Adolescents: Acute and Recent (Early) HIV infection.

clinical latency stage

After the acute stage of HIV infection, the disease moves into a stage called the “clinical latency” stage. “Latency” means a period where a virus is living or developing in a person without producing symptoms. During the clinical latency stage, people who are infected with HIV experience no HIV-related symptoms, or only mild ones. (This stage is sometimes called “asymptomatic HIV infection” or “chronic HIV infection.”)

During the clinical latency stage, the HIV virus continues to reproduce at very low levels, although it is still active. If you take ART, you may live with clinical latency for several decades because treatment helps keep the virus in check. (Read more about HIV treatment.) For people who are not on ART, the clinical latency stage lasts an average of 10 years, but some people may progress through this stage faster.

It is important to remember that people in this symptom-free stage are still able to transmit HIV to others, even if they are on ART, although ART greatly reduces the risk of transmission.

If you have HIV and you are not on ART, then eventually your viral load will begin to rise and your CD4 count will begin to decline. As this happens, you may begin to have constitutional symptoms of HIV as the virus levels increase in your body.

AIDS

This is the stage of HIV infection that occurs when your immune system is badly damaged and you become vulnerable to infections and infection-related cancers called opportunistic infections. When the number of your CD4 cells falls below 200 cells per cubic millimeter of blood (200 cells/mm3), you are considered to have progressed to AIDS. (In someone with a healthy immune system, CD4 counts are between 500 and 1,600 cells/mm3.) You are also considered to have progressed to AIDS if you develop one or more opportunistic illnesses, regardless of your CD4 count.

Without treatment, people who progress to AIDS typically survive about 3 years. Once you have a dangerous opportunistic illness, life-expectancy without treatment falls to about 1 year. However, if you are taking ART and maintain a low viral load, then you may enjoy a near normal life span. You will most likely never progress to AIDS.

Factors Affecting Disease Progression

People living with HIV may progress through these stages at different rates, depending on a variety of factors, including their genetic makeup, how healthy they were before they were infected, how soon after infection they are diagnosed and linked to care and treatment, whether they see their healthcare provider regularly and take their HIV medications as directed, and different health-related choices they make, such as decisions to eat a healthful diet, exercise, and not smoke.

Time between HIV infection and AIDS

Factors that may shorten the time between HIV and AIDS:

  • Older age
  • HIV subtype
  • Co-infection with other viruses
  • Poor nutrition
  • Severe stress
  • Your genetic background

Factors that may delay the time between HIV and AIDS:

  • Taking antiretroviral therapy
  • Staying in HIV care
  • Closely adhering to your doctor’s recommendations
  • Eating healthful foods
  • Taking care of yourself
  • Your genetic background

By making healthy choices, you have some control over the progression of HIV infection.

To learn more, see CDC’s Living with HIV.


As noted above, when used consistently, ART prevents the HIV virus from multiplying and from destroying your immune system. And there are other treatments that can prevent or cure some of the illnesses associated with AIDS, though the treatments do not cure HIV itself. The earlier you detect your HIV infection and start treatment, the better.

But not everyone is diagnosed early. Some people are diagnosed with HIV and AIDS concurrently, meaning that they have been living with HIV for a long time and the virus has already done damage to their body by the time they find out they are infected. These individuals need to seek a healthcare provider immediately and be linked to care so that they can stay as healthy as possible, as long as possible. Use the HIV Testing and Services Locator to find an HIV provider near you.

Frequently Asked Questions

Is HIV always fatal?

Most people who do not receive treatment for HIV will eventually (over years) become ill and die of complications of HIV infection. With ART, however, most people with HIV infection can lead long and healthy lives. This is especially true if they start HIV treatment when their immune system is still relatively strong. For this reason, it is very important to find an HIV provider and work with him or her to develop a treatment plan that works for you. Visit the HIV Testing and Services Locator to find an HIV provider near you.

Additional Resources

Last revised: 12/19/2013