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PEPFARThe U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world.  This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments also help alleviate suffering from other diseases across the global health spectrum.  PEPFAR is driven by a shared responsibility among donor and partner nations and others to make smart investments to save lives. Read more about PEPFAR’s priorities and results in this fact sheet (PDF 391 KB).

The Office of the U.S. Global AIDS Coordinator manages PEPFAR. The Coordinator is appointed by the President and confirmed by the Senate to coordinate and oversee the U.S. global response to HIV/AIDS. Reporting directly to the Secretary of State, the U.S. Global AIDS Coordinator:

  • Leads the U.S. Government's international HIV/AIDS efforts;
  • Ensures program and policy coordination among the relevant USG agencies and departments and nongovernmental organizations, avoiding duplication of effort;
  • Pursues coordination with other countries and international organizations;
  • Resolves policy, program, and funding disputes among the relevant USG agencies and departments;
  • Directly approves all activities of the United States relating to combating HIV/AIDS in 15 focus countries; and
  • Promotes program accountability and monitor progress toward meeting the Emergency Plan's goals.

Deborah L. Birx, M.D. is Ambassador-at-Large and Coordinator of the United States Government activities to combat HIV/AIDS globally. As Global AIDS Coordinator, Ambassador Birx oversees the implementation of PEPFAR, as well as all U.S. Government engagement with the Global Fund to Fight AIDS, Tuberculosis and Malaria. (Read Ambassador Birx’s bio here. Read blog posts on by Ambassador Birx)

  • Read posts about PEPFAR on the blog
  • Read posts about PEPFAR on DipNote, the U.S. State Department’s blog

Global Health Initiative

PEPFAR is the cornerstone and largest component of the U.S. President’s Global Health Initiative (GHI). GHI is the umbrella that links the efforts of U.S. Government health programming into a unified health strategy. GHI pulls together U.S. Government efforts to dramatically reduce the burden of illness and death from some of the world’s most devastating diseases: HIV and AIDS, tuberculosis, malaria, and neglected tropical diseases. GHI has also established ambitious goals to address unacceptable rates of maternal and child mortality. In addition, GHI is working to expand local capacity and self-sufficiency in partner countries. A complete list of targets can be found on

PEPFAR's Targets for Fiscal Years 2010-2014


  • support the prevention of more than 12 million new HIV infections;
  • ensure that every partner country with a generalized epidemic  has both 80% coverage of testing for pregnant women at the national level, and 85% coverage of antiretroviral drug (ARV) prophylaxis and treatment, as indicated, of women found to be HIV-infected;
  • double the number of at-risk babies born HIV-free, from the 240,000 babies of HIV-positive mothers who were born HIV-negative during the first five years of PEPFAR;
  • in every partner country with a generalized epidemic, provide 100% of youth in PEPFAR prevention programs with comprehensive and correct knowledge of the ways HIV/AIDS is transmitted and ways to protect themselves, consistent with Millennium Development Goal indicators in this area.

Care, Support and Treatment

  • provide direct support for more than 4 million people on treatment, more than doubling the number of people directly supported on treatment during the first five years of PEPFAR;
  • support care for more than 12 million people, including 5 million orphans and vulnerable children; and
  • ensure that every partner country with a generalized epidemic reaches a threshold of 65% coverage for early infant diagnosis at the national level, and testing of 80% of older children of HIV-positive mothers, with increased referrals and linkages to care and treatment.


  • support training and retention of more than 140,000 new health care workers to strengthen health systems;
  • in order to support country ownership, ensure that in each country with a major PEPFAR investment (greater than $5 million), the partner government leads efforts to evaluate and define needs and roles in the national response; and
  • ensure that in every partner country with a Partnership Framework, each country will change policies to address the larger structural conditions, such as gender-based violence, stigma, or low male partner involvement, which contribute to the spread of the epidemic.

Implementing Agencies

Learn about the U.S. government agencies that have come together in the common cause of turning the tide against the HIV/AIDS pandemic.


View information about PEPFAR-supported efforts and related resources in participating countries.

PEPFAR’s Program Results

Annually, PEPFAR reports on results achieved by its programs across the range of prevention, treatment and care programs.  Reflecting America’s commitment to saving lives affected by HIV/AIDS, PEPFAR is supporting countries in providing HIV prevention, treatment and care to their people.

  • As of September 30, 2013, PEPFAR is supporting life-saving antiretroviral treatment for 6.7 million men, women and children worldwide.  This far exceeds President Obama’s 2011 World AIDS Day goal of 6 million people on treatment—a four-fold increase (from 1.7 million in 2008) since the start of this Administration.
  • In Fiscal Year (FY) 2013,PEPFAR supported HIV testing and counseling for more than 12.8 million pregnant women. For 780,000 of these women who tested positive for HIV, PEPFAR provided antiretroviral medications to prevent mother-to-child transmission of the virus. Due to PEPFAR support, 95 percent of those babies were born HIV-free (including 240,000 that would otherwise have been infected).
    • Over the past two years, over 1.5 million HIV-positive pregnant women received these interventions to prevent mother-to-child transmission and improve maternal health, meeting the President’s 2011 World AIDS Day Goal.
  • As of September 30, 2013, PEPFAR will have supported more than 4.2 million voluntary medical male circumcision (VMMC) procedures in east and southern Africa; by the end of 2013, PEPFAR will have reached the President’s 2011 World AIDS Day VMMC goal of 4.7 million.
  • PEPFAR directly supported 17 million people with care and support, including more than 5 million orphans and vulnerable children, in FY 2013.  
  • PEPFAR supported HIV counseling and testing for more than 57.7 million people in FY 2013, providing a critical entry point to prevention, treatment, and care.  
  • The U.S. is the first and largest donor to the Global Fund to Fight AIDS, Tuberculosis and Malaria. As a result of the significant investment by the U.S. in the Global Fund, of the estimated 9.7 million individuals in low- and middle-income countries who currently receive treatment, nearly 9.1 million receive support through PEPFAR bilateral programs, the Global Fund, or both.

Read more about PEPFAR's results and progress to date.

Last revised: 10/31/2014